Alterations of the DR5/TRAIL Receptor 2 Gene in Non-Small Cell Lung Cancers
作者： Seo Young Han , Sug Hyung Lee , Ro Ra Oh , Hong Sug Kim , Nam Jin Yoo
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摘要: Chromosome 8p21-22 is a frequent site of allelic deletions in many types human tumors, including non-small cell lung cancer (NSCLC). Tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2) cell-surface receptor involved death signaling. The TRAIL-R2 gene recently has been mapped to chromosome 8p21-22. To explore the possibility that might be relevant deletion NSCLC, we have analyzed entire coding region and all splice sites for detection somatic mutations series 104 NSCLCs. Overall, 11 tumors (10.6%) were found domain known transduction an apoptotic signal. Our data indicate mutation may play role pathogenesis some NSCLCs one genes loss NSCLC.
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