The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila
作者： Gary N. Landis , Matthew P. Salomon , Daniel Keroles , Nicholas Brookes , Troy Sekimura
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摘要: Mating causes decreased life span in female Drosophila. Here we report that mifepristone blocked this effect, yielding increases up to +68%. Drug was fed females after mating, the absence of males, demonstrating function females. Mifepristone did not increase virgin or males. reduced progeny production but reduce food intake. High-throughput RNA sequencing used identify genes up-regulated down-regulated upon and where change by mifepristone. Five candidate positive regulators were identified, including dosage compensation regulator Unr three X-linked genes: multi sex combs (PcG gene), Dopamine 2-like receptor CG14215. The 37 negative included neuropeptide CNMamide several involved protein mobilization immune response. results inform interpretation experiments involving mifepristone, implicate steroid hormone signaling regulating trade-off between reproduction span.
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