MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship
DOI: 10.1038/NRG3162
关键词:
摘要: MicroRNAs (miRNAs) have emerged as key gene regulators in diverse biological pathways. These small non-coding RNAs bind to target sequences mRNAs, typically resulting repressed expression. Several methods are now available for identifying miRNA sites, but the mere presence of an miRNA-binding site is insufficient predicting regulation. Regulation targets by miRNAs subject various levels control, and recent developments presented a new twist; can reciprocally control level function miRNAs. This mutual regulation genes challenging our understanding gene-regulatory role vivo has important implications use these therapeutic settings.
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