Carbon monoxide–releasing molecule-3: Amelioration of renal ischemia reperfusion injury in a rat model

摘要: Purpose Despite the role of carbon monoxide in ameliorating ischemia-reperfusion injury (IRI), its use clinical setting is restricted owing to toxicity. Herein, we investigated vivo effects monoxide-releasing molecule-3 (CORM-3) on IRI. Materials and Methods Fifteen rats were equally randomly divided into three groups: sham (right nephrectomy), control nephrectomy left renal ischemia), CORM-3 injection before ischemia). Kidney tissues blood samples collected from sacrificed evaluated determine renoprotective effect mechanism CORM-3. Results Concentrations serum creatinine kidney molecule-1 group significantly lower than after 75 minutes IRI (1.2 vs. 2.4 mg/dL, p=0.01, 292 550 pg/mL, p<0.001, respectively). Furthermore, exhibited a higher portion normal tubules glomeruli. TUNEL staining revealed fewer apoptotic tubular cells group. The expression 960 genes was also altered. Pretreatment with produced significant effect. altered found be involved peroxisome proliferator-activated receptors signaling pathway, difference these between groups statistically (p<0.001). Conclusions ameliorates by decreasing apoptosis may novel strategy for protection against warm