Intravenous sildenafil as a preconditioning drug against hemodynamic consequences of warm ischemia-reperfusion on the kidney.
作者： Enrique Lledo-Garcia , David Subira-Rios , Gabriel Ogaya-Pinies , Alberto Tejedor-Jorge , Juan Francisco Del Cañizo-Lopez
DOI: 10.1016/J.JURO.2011.03.036
关键词:
摘要: Purpose: We designed an experimental model of renal ischemia-reperfusion to evaluate the preemptive effect intravenous sildenafil according dose administered (0.7 vs 1.4 mg/kg) and time administration (30 minutes before ischemia or during ischemia).Materials Methods: A total 20 minipigs were divided into groups 4 each, including group 1—control, 2—sildenafil 0.7 mg/kg intravenously 30 vascular clamping, 3—sildenafil warm ischemia, 4—sildenafil clamping 5—sildenafil ischemia. The was applied using laparotomy right kidney for minutes, followed by unclamping reperfusion 45 minutes. Renal flow systemic mean arterial pressure recorded after unclamping. Mean values compared Student t test with significance considered at p <0...
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