Alterations in stromal glycoconjugates in macular corneal dystrophy.

摘要: Nine biotinylated lectins were used as histochemical probes to localize the carbohydrates residues of glycoconjugates in normal corneas and with macular granular dystrophy. The lectin binding patterns dystrophy indistinguishable from one another, but distinctly different those found Concanavalin A reacted weakly corneal stromal matrix, stained matrix intensely. Furthermore, unlike positively wheat germ agglutinin (WGA), Ricinus communis I (RCA-I), Ulex europeus I, Dolichos biflorus, Bandeiraea simplicifolia II, soybean peanut lectins. This study demonstrates specific alterations which occur patients dystrophy, namely presence oligosaccharides terminal alpha-fucose, beta-galactose, N-acetylglucosamine N-acetylgalactosamine residues, oligosaccharide chains a beta-galactose-N-acetylgalactosamine sequence.