Effects of a herbal gel containing carvacrol and chalcones on alveolar bone resorption in rats on experimental periodontitis
作者： Marco Antonio Botelho , Vietla Satyanarayana Rao , Danusa Montenegro , Mary Anne Menezes Bandeira , Said Gonçalves Cruz Fonseca
DOI: 10.1002/PTR.2325
关键词:
摘要: Carvacrol and dimeric chalcones are the respective bioactive components of Lippia sidoides Myracrodruon urundeuva, popular medicinal plants Northeastern Brazil with proven antimicrobial antiinflammatory properties. Periodontal disease is associated inflammation microbiological proliferation, thus study aimed to investigate effect a topical gel based on carvacrol in experimental periodontal (EPD) rats. Animals were treated and/or gel, immediately after EPD induction, three times day for 11 days. Appropriate controls included study. weighed daily. They killed 11, mandibles dissected alveolar bone loss was measured. The periodontium examined at histopathology neutrophil influx into gingiva assayed using myeloperoxidase activity. bacterial flora assessed through culture gingival tissue. Alveolar significantly (p < 0.05) inhibited by combined compared vehicle non-treated groups. treatment reduced tissue lesion histopathology, decreased activity growth oral microorganisms as well weight loss. combination has beneficial upon this model.
sci-hub.se 参考文章(29)
I Takazoe, K Okuda, K Osawa, T Matsumoto, T Takiguchi, T Maruyama, Studies of the antibacterial activity of plant extracts and their constituents against periodontopathic bacteria. The Bulletin of Tokyo Dental College. ,vol. 31, pp. 17- 21 ,(1990)
Kaplow Ls, The relationship of myeloperoxidase activity to neutrophil maturity and other hematologic indicators of infection. Blood cells. ,vol. 12, pp. 153- 165 ,(1986)
PP Bradley, RD Christensen, G Rothstein, Cellular and Extracellular Myeloperoxidase in Pyogenic Inflammation Blood. ,vol. 60, pp. 618- 622 ,(1982) , 10.1182/BLOOD.V60.3.618.618
D. H. Fine, D. Furgang, M. L. Barnett, C. Drew, L. Steinberg, C. H. Charles, J. W. Vincent, Effect of an essential oil-containing antiseptic mouthrinse on plaque and salivary Streptococcus mutans levels. Journal of Clinical Periodontology. ,vol. 27, pp. 157- 161 ,(2000) , 10.1034/J.1600-051X.2000.027003157.X
M.A. Botelho, V.S. Rao, C.B.M. Carvalho, J.G. Bezerra-Filho, S.G.C. Fonseca, M.L. Vale, D. Montenegro, F. Cunha, R.A. Ribeiro, G.A. Brito, Lippia sidoides and Myracrodruon urundeuva gel prevents alveolar bone resorption in experimental periodontitis in rats. Journal of Ethnopharmacology. ,vol. 113, pp. 471- 478 ,(2007) , 10.1016/J.JEP.2007.07.010
J. W. Alencar, A. A. Craveiro, F. J. A. Matos, Kovats' Indices as a Preselection Routine in Mass Spectra Library Searches of Volatiles Journal of Natural Products. ,vol. 47, pp. 890- 892 ,(1984) , 10.1021/NP50035A028
John M. Crawford, Martin A. Taubman, Daniel J. Smith, The natural history of periodontal bone loss in germfree and gnotobiotic rats infected with Periodontopathic microorganisms Journal of Periodontal Research. ,vol. 13, pp. 316- 325 ,(1978) , 10.1111/J.1600-0765.1978.TB00186.X
Hongtao Liu, Richard M Pope, Phagocytes: mechanisms of inflammation and tissue destruction. Rheumatic Diseases Clinics of North America. ,vol. 30, pp. 19- 39 ,(2004) , 10.1016/S0889-857X(03)00107-8
V.C.C. Girão, D.C.S. Nunes-Pinheiro, S.M. Morais, J.L. Sequeira, M.A. Gioso, A clinical trial of the effect of a mouth-rinse prepared with Lippia sidoides Cham essential oil in dogs with mild gingival disease. Preventive Veterinary Medicine. ,vol. 59, pp. 95- 102 ,(2003) , 10.1016/S0167-5877(03)00051-5
Adriana MA Menezes, Francisco Airton C Rocha, Hellíada V Chaves, Cibele BM Carvalho, Ronaldo A Ribeiro, Gerly Anne C Brito, None, Effect of Sodium Alendronate on Alveolar Bone Resorption in Experimental Periodontitis in Rats Journal of Periodontology. ,vol. 76, pp. 1901- 1909 ,(2005) , 10.1902/JOP.2005.76.11.1901