Disruption of Akt kinase activation is important for immunosuppression induced by measles virus

摘要: Surface-contact–mediated signaling induced by the measles virus (MV) fusion and hemagglutinin glycoproteins is necessary sufficient to induce T-cell unresponsiveness in vitro vivo. To define intracellular pathways involved, we analyzed interleukin (IL)-2R primary human T cells Kit-225 cells. Unlike IL-2–dependent activation of JAK/STAT pathways, Akt kinase was impaired after MV contact both interference with important for immunosuppression, as expression a catalytically active prevented negative glycoproteins. Thus, show here that exploits novel strategy interfere during immunosuppression.