Simple Multiresidue Determination of Fluoroquinolones in Bovine Milk by Liquid Chromatography with Fluorescence Detection
作者： M. Hassouan , O. Ballesteros , J. Vílchez , A. Zafra , A. Navalón
DOI: 10.1080/00032710601017912
关键词:
摘要: Abstract A simple and sensitive method for the simultaneous determination of five fluoroquinolones (ciprofloxacin, enrofloxacin, danofloxacin, difloxacin, sarafloxacin) in bovine milk was developed. Protein precipitation from samples achieved by addition acetonitrile o‐phosphoric acid. Acetonitrile removed with dichloromethane, leaving acid aqueous extract. The extract analyzed liquid chromatography fluorescence detection (LC–FD). mobile phase composed 10 mM citrate buffer solution pH 4.5, an initial composition acetonitrile‐water (12∶88, v/v) using linear gradient elution. Norfloxacin used as internal standard. limits found ranged 1 to 6 ng · mL−1 were below maximum residue (MRLs) established European Union. proposed applied these compounds different samples. Method validation car...
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