Molecular Classification of Gastric Adenocarcinoma: Translating New Insights from The Cancer Genome Atlas Research Network

摘要: Gastric cancer is a heterogenous cancer, which may be classified into several distinct subtypes based on pathology and epidemiology, each with different initiating pathological processes possibly having tumor biology. A classification of gastric should important to select patients who can benefit from the targeted therapies or precisely predict prognosis. The Cancer Genome Atlas (TCGA) study collaborated previous reports regarding subtyping but also proposed refined molecular characteristics. addition new strategy current classical promising option, particularly stratification by Epstein–Barr virus (EBV) microsatellite instability (MSI) statuses. According TCGA study, EBV programmed cell death protein 1 (PD-1)/programmed death-ligand (PD-L1) antibodies phosphoinositide 3-kinase (PI3K) inhibitors are now being developed. discoveries predictive biomarkers improve patient care individualized medicine in management since have potential change landscape treatment, moreover leading both better understanding heterogeneity outcomes. Patient enrichment for treatment strategies will critical clinical Additionally, liquid biopsies able enable us monitor real-time escape mechanism, resulting strategies.