Biologically effective doses of postoperative radiotherapy in the prevention of keloids. Dose-effect relationship.

摘要: To review the recurrence rates of keloids after surgical excision followed by radiotherapy, and to answer question whether normalization dose, a dose-effect relationship could be derived. A literature search was performed identify studies dealing with efficacy various irradiation regimens for prevention surgery. Biologically effective doses (BEDs) were calculated using linear-quadratic concept. distinction between in face neck region those other parts body made. 31 reports identified PubMed terms keloids, surgery, radiation therapy, radiotherapy. 13 excluded, because no link found rate or if less than ten patients per dose group. The surgery only 50–80%. For BED values > 10 Gy decreased as function BED. 30 < 10%. given sites high stretch tension not significantly higher without tension. results this study indicate that effectively treating postoperatively, relatively must applied short overall treatment time. optimal probably is an scheme resulting value at least Gy. can obtained with, instance, single acute Gy, two fractions 8 three 6 27 low rate. should administered within 2 days