Abnormal development in the skin of the pupoid fetus (pf/pf) mutant mouse: abnormal keratinization, recovery of a normal phenotype, and relationship to the repeated epilation (Er/Er) mutant mouse.

摘要: Publisher Summary There are many mutations of the mouse that affect epidermal differentiation. The great majority these affects hair development and one (hairless) expression mutant gene has been localized to epidermis. Mutations resulting in failure keratinization much rarer, perhaps due disastrous consequences affecting such a fundamental process. Recently, however, an autosomal recessive mutation complete terminal differentiation epidermis was described. This chapter describes various aspects abnormal pupoid fetus ( pf/pf ) skin. It both morphological biochemical abnormalities epidermis, discusses efforts localize site expression, reports attempts understand shortcomings embryonic regulation cause abnormalities. also explores similarities between pf related repeated epilation Er mouse.