Treatment of hypoxic-ischemic encephalopathy in newborns

摘要: Hypoxic-ischemic (HI) brain injury is the most common cause of encephalopathy and seizures in term newborn infants. There no single, valid test for birth asphyxia leading to HI injury, thus this disorder often poorly characterized, timing etiology can be difficult ascertain. Optimal management involves prompt resuscitation, careful supportive care including prevention hyperthermia hypoglycemia, treatment clinical frequent or prolonged subclinical seizures. Recent evidence suggests that therapeutic hypothermia by selective head whole-body cooling administered within 6 hours reduces incidence death moderate/severe disability at 12 22 months. Hypothermia a promising new therapy physicians should consider context registry study. seizure remains controversial because widely used drug, phenobarbital, has limited efficacy, value monitoring treating uncertain. compelling need well-designed trials address ongoing setting hypoxia-ischemia Emerging from preclinical studies future neonatal will combine novel neuroprotective anti-seizure agents. Pilot newer anticonvulsants are provide critical information