Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.

摘要: Circulating white blood cell (WBC) counts (neutrophils, monocytes, lymphocytes, eosinophils, basophils) differ by ethnicity. The genetic factors underlying basal WBC traits in Hispanics/Latinos are unknown. We performed a genome-wide association study of total and differential large, ethnically diverse US population sample ascertained the Hispanic Community Health Study Latinos (HCHS/SOL). demonstrate that several previously known WBC-associated loci (e.g. African Duffy antigen receptor for chemokines null variant neutrophil count) generalizable to Hispanics/Latinos. identified replicated common rare germ-line variants at FLT3 (a gene often somatically mutated leukemia) associated with monocyte count. rs76428106 has large allele frequency between non-African populations. also novel involving or regulating hematopoietic transcription (CEBPE-SLC7A7, CEBPA CRBN-TRNT1) basophil minor CEBPE lower count been Amerindian ancestry higher risk acute lymphoblastic leukemia Hispanics. Together, these data suggest germline variation affecting transcriptional signaling pathways underlie development lineage specification can contribute inter-individual as well ethnic differences peripheral (normal hematopoiesis) addition susceptibility (malignant hematopoiesis).