A Comparison of Tumor Biology in Primary Ductal Carcinoma In Situ Recurring as Invasive Carcinoma versus a New In Situ.

摘要: Introduction. About half of all new ipsilateral events after a primary ductal carcinoma in situ (DCIS) are invasive carcinoma. We studied tumor markers the DCIS relation to type event (invasive versus situ). Methods. Two hundred and sixty-six women with from two source populations, known event, were included. All regarded as recurrences. Patient characteristics (estrogen receptor (ER), progesterone (PR), HER2, EGFR, Ki67) evaluated. Logistic regression was used calculate odd ratios 95% confidence intervals univariate multivariate analyses. Results. One thirty-six recurrences 130 situ. The recurrence more often if ER+ (OR 2.5, CI 1.2–5.1). Primary being HER2+ 0.5, 0.3–0.9), EGFR+ 0.4, 0.2–0.9), ER95−/HER2+ 0.2, 0.1–0.6) had lower risk invasive. Conclusions. In this study, comparing showed that ER−/HER2+ tumors related DCIS. And surprisingly, ER+, HER2−, EGFR− cancer.