Potent antitumor and antineoplastic efficacy of baicalein on benzo(a)pyrene-induced experimental pulmonary tumorigenesis.

摘要: Current study aims to evaluate the efficacy of baicalein (BE), a naturally occurring bioactive flavanoid (5,6,7-trihydroxy-flavone), at dose 12 mg/kg body wt in Swiss albino mice exposed tobacco-specific carcinogen benzo(a)pyrene [B(a)P] (50 wt) for its ability mitigate pulmonary adenoma formation and growth. Under coarse observation, B(a)P-administered mice, after 16 weeks, developed macroscopically detectable tumors, whereas oral treatment with BE lung cancer-induced significantly reduced tumor incidence 16-week pre- posttreated groups. A detailed histopathological examination was conducted determine degree cancer progression. Incidence anaplasia, hyperplasia, dysplasia, severe adenocarcinoma were evident carcinogen-administrated group 6, 10, 12, 14, 16th respectively, these anomalies effectively posttreatment BE. In pretreatment group, arrested multiplicity by approximately 65% load 88%, while posttreatment, compound 48% 61%. Further analysis serum markers like carcinoembryonic antigen, CK 19 fragments (CYFRA 21-1), tissue marker enzymes aryl hydrocarbon hydroxylase, adenosine deaminase, γ-glutamyl transpeptidase, 5'-nucleotidase, lactate dehydrogenase homogenate carried out substantiate anticarcinogenic effect The overall data from our experiments suggested that inhibited growth, thus revealing potent antitumorigenic effect.