The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease
作者： O. S. Gorbatyuk , S. Li , L. F. Sullivan , W. Chen , G. Kondrikova
关键词:
摘要: … and S129D mutants at 8 wk postinjection (140 and 130 ng/100 μg, respectively), and no significant difference in the expression of human wt α-syn at different times after injection when …
harvard.edu
jstor.org 
sci-hub.se 参考文章(28)
Hideo Fujiwara, Masato Hasegawa, Naoshi Dohmae, Akiko Kawashima, Eliezer Masliah, Matthew S. Goldberg, Jie Shen, Koji Takio, Takeshi Iwatsubo, |[alpha]|-Synuclein is phosphorylated in synucleinopathy lesions Nature Cell Biology. ,vol. 4, pp. 160- 164 ,(2002) , 10.1038/NCB748
Deniz Kirik, Carl Rosenblad, Corinna Burger, Cecilia Lundberg, Teit E. Johansen, Nicholas Muzyczka, Ronald J. Mandel, Anders Björklund, Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. The Journal of Neuroscience. ,vol. 22, pp. 2780- 2791 ,(2002) , 10.1523/JNEUROSCI.22-07-02780.2002
Alexey N. Pronin, Andrew J. Morris, Andrei Surguchov, Jeffrey L. Benovic, Synucleins Are a Novel Class of Substrates for G Protein-coupled Receptor Kinases Journal of Biological Chemistry. ,vol. 275, pp. 26515- 26522 ,(2000) , 10.1074/JBC.M003542200
Li Chen, Mel B Feany, α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease Nature Neuroscience. ,vol. 8, pp. 657- 663 ,(2005) , 10.1038/NN1443
Corinna Burger, Oleg S Gorbatyuk, Margaret J Velardo, Carmen S Peden, Philip Williams, Sergei Zolotukhin, Paul J Reier, Ronald J Mandel, Nicholas Muzyczka, None, Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Molecular Therapy. ,vol. 10, pp. 302- 317 ,(2004) , 10.1016/J.YMTHE.2004.05.024
Atsushi Iwata, Seiko Miura, Ichiro Kanazawa, Makoto Sawada, Nobuyuki Nukina, alpha-Synuclein forms a complex with transcription factor Elk-1. Journal of Neurochemistry. ,vol. 77, pp. 239- 252 ,(2001) , 10.1046/J.1471-4159.2001.T01-1-00232.X
Masayasu Okochi, Jochen Walter, Akihiko Koyama, Shigeo Nakajo, Minami Baba, Takeshi Iwatsubo, Laurent Meijer, Philipp J. Kahle, Christian Haass, Constitutive Phosphorylation of the Parkinson's Disease Associated α-Synuclein * Journal of Biological Chemistry. ,vol. 275, pp. 390- 397 ,(2000) , 10.1074/JBC.275.1.390
Chao Liu, Erkang Fei, Nali Jia, Hongfeng Wang, Ruisong Tao, Atsushi Iwata, Nobuyuki Nukina, Jiangning Zhou, Guanghui Wang, None, Assembly of Lysine 63-linked Ubiquitin Conjugates by Phosphorylated α-Synuclein Implies Lewy Body Biogenesis Journal of Biological Chemistry. ,vol. 282, pp. 14558- 14566 ,(2007) , 10.1074/JBC.M700422200
Masaki Wakamatsu, Aiko Ishii, Yuriko Ukai, Junko Sakagami, Shingo Iwata, Mieko Ono, Kayo Matsumoto, Atsushi Nakamura, Norihiro Tada, Kazuto Kobayashi, Takeshi Iwatsubo, Makoto Yoshimoto, Accumulation of phosphorylated α-synuclein in dopaminergic neurons of transgenic mice that express human α-synuclein Journal of Neuroscience Research. ,vol. 85, pp. 1819- 1825 ,(2007) , 10.1002/JNR.21310
Xiangmin M Peng, Roya Tehranian, Paula Dietrich, Leonidas Stefanis, Ruth G Perez, α-Synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells Journal of Cell Science. ,vol. 118, pp. 3523- 3530 ,(2005) , 10.1242/JCS.02481