Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results data, 1973 to 2009

摘要: BACKGROUND Paranasal sinus squamous cell carcinomas (PNSSCC) account for 3% of all head and neck malignancies. There has been little information on the trends in incidence survival, no randomized trials have conducted to guide therapy. METHODS Patients with PNSSCC reported Surveillance, Epidemiology, End Results (SEER) Program from 1973 through 2009 were categorized by sex, age, year diagnosis, primary site, stage, treatment. The survival then compared across different demographic disease-related categories calculating rate ratios (RRs) mortality hazard along corresponding 95% confidence intervals (CIs). RESULTS In total, 2553 patients identified. While showed a gradual decline, remained largely unchanged. proportion advanced disease decreased 14.7% during period 1983 1992 12.4% 1993-2002 9.5% 2003-2009. Compared whites, was higher among African Americans (RR 1.63; CI, 1.39, 1.90) other racial groups (RR, 1.78; CI: 1.53-2.07). After adjusting tumor treatment, American also increased (hazard ratio, 1.22; 1.04-1.43). Among localized disease, relation between race longer evident once results controlled classification. CONCLUSIONS The current findings point disparities and, lesser extent, outcome PNSSCC. Although there decline presenting PNSSCC, overall stable over time. Cancer 2013;119:2602–2610. © 2013 Society.