Assembly of the Truncated Immunoglobulin Heavy Chain Dμ into Antigen Receptor–Like Complexes in Pre-B Cells but Not in B Cells
作者： Mary C Horne , Patricia E Roth , Anthony L DeFranco
DOI: 10.1016/S1074-7613(00)80679-2
关键词:
摘要: Rearrangements of the IgH locus with JH joined to reading frame 2 DH are greatly underrepresented in B cells. These rearrangements encode truncated heavy chain D mu. In pre-B cells, we found mu protein expressed on cell surface and assembled into a complex surrogate light chains, Ig alpha, beta. Cross-linking either m- or containing receptors triggered signal transduction reactions. contrast, when mature lines, was not detected did efficiently bind kappa immunoglobulin but associate alpha results characterize interactions other components antigen receptor suggest possible mechanisms by which expression may interfere development.
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sci-hub.se 参考文章(77)
S. Pillai, D. Baltimore, The Omega and Iota Surrogate Immunoglobulin Light Chains Genetics of Immunological Diseases. ,vol. 137, pp. 136- 139 ,(1988) , 10.1007/978-3-642-50059-6_20
A. Iglesias, M. Kopf, G.S. Williams, B. Bühler, G. Köhler, Molecular requirements for the mu-induced light chain gene rearrangement in pre-B cells. The EMBO Journal. ,vol. 10, pp. 2147- 2155 ,(1991) , 10.1002/J.1460-2075.1991.TB07749.X
T. Takemori, J. Mizuguchi, I. Miyazoe, M. Nakanishi, K. Shigemoto, H. Kimoto, T. Shirasawa, N. Maruyama, M. Taniguchi, Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells. The EMBO Journal. ,vol. 9, pp. 2493- 2500 ,(1990) , 10.1002/J.1460-2075.1990.TB07428.X
Y. Chang, C.J. Paige, G.E. Wu, Enumeration and characterization of DJH structures in mouse fetal liver. The EMBO Journal. ,vol. 11, pp. 1891- 1899 ,(1992) , 10.1002/J.1460-2075.1992.TB05241.X
M. Takata, H. Sabe, A. Hata, T. Inazu, Y. Homma, T. Nukada, H. Yamamura, T. Kurosaki, Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. The EMBO Journal. ,vol. 13, pp. 1341- 1349 ,(1994) , 10.1002/J.1460-2075.1994.TB06387.X
R. R. Hardy, J. D. Kemp, K. Hayakawa, Analysis of Lymphoid Population in Scid Mice; Detection of a Potential B Lymphocyte Progenitor Population Present at Normal Levels in Scid Mice by Three Color Flow Cytometry With B220 and S7 Current Topics in Microbiology and Immunology. ,vol. 152, pp. 19- 25 ,(1989) , 10.1007/978-3-642-74974-2_3
T. Taniguchi, T. Kobayashi, J. Kondo, K. Takahashi, H. Nakamura, J. Suzuki, K. Nagai, T. Yamada, S. Nakamura, H. Yamamura, Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. Journal of Biological Chemistry. ,vol. 266, pp. 15790- 15796 ,(1991) , 10.1016/S0021-9258(18)98478-4
H. Gu, I. Förster, K. Rajewsky, Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation. The EMBO Journal. ,vol. 9, pp. 2133- 2140 ,(1990) , 10.1002/J.1460-2075.1990.TB07382.X
M. Reth, E. Petrac, P. Wiese, L. Lobel, F. W. Alt, Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains. The EMBO Journal. ,vol. 6, pp. 3299- 3305 ,(1987) , 10.1002/J.1460-2075.1987.TB02649.X
J H Blum, T L Stevens, A L DeFranco, Role of the Mu Immunoglobulin Heavy Chain Transmembrane and Cytoplasmic Domains in B Cell Antigen Receptor Expression and Signal Transduction Journal of Biological Chemistry. ,vol. 268, pp. 27236- 27245 ,(1993) , 10.1016/S0021-9258(19)74242-2