Combined p21WAF1/CIP1 and p53 overexpression predict improved survival in muscle-invasive bladder cancer treated by radical radiotherapy.

摘要: Abstract Purpose: The prognostic value of p21 and p53 expression was evaluated for patients with muscle-invasive bladder cancer treated by radical radiotherapy. Methods Materials: Sixty-eight paraffin-embedded sections from surgically resected tumors taken prior to irradiation were immunostained p53. Results: Nuclear staining demonstrated in 32/68 (47%) 46/68 (68%) tumors, respectively. There no correlation between immunopositivity this group ( r = 0.067, p 0.56). Patients stratified into four distinct groups depending on p53: p21+p53+, p21+p53−, p21−p53+, p21−p53−. p21+p53+ had the best prognosis a 3-year survival 82% compared 12% p21−p53+ 0.0031), 29% p21+p53− 0.0108); 45% p21−p53− 0.0375). also significantly improved when combined analysis performed p21−p53−, (3-year survival=30%, 0.0062). In multivariate model, 0.0108, relative risk [RR] 5.18) complete/partial response 0.0019, RR=3.76) only independent predictors survival. Conclusions: With radiotherapy, stratification identifies groups, being associated worst.