Lifetime physical activity and the risk of renal cell cancer

摘要: The relation between lifelong physical activity at work and during leisure-time the risk of renal cell cancer (RCC) was analyzed in a case-control study conducted Italy 1992 2004. Cases were 767 subjects with incident, histologically confirmed RCC, controls 1,534 patients hospitalized for acute nonneoplastic conditions. Odds ratios (OR) 95% confidence intervals (CI) RCC computed by multiple logistic regression models, conditioned on center, sex age, adjusted main covariates. Compared to lowest level occupational activity, multivariate OR highest 0.65 (95% CI 0.49-0.87) age 12 years, 0.67 0.53-0.84) 15-19, 0.74 0.59-0.93) 30-39 0.71 0.55-0.92) 50-59 significant inverse trends risk. association consistent strata sex, diagnosis, body mass index, smoking habit alcohol drinking. No found activity. risk, if real, may be related effects insulin-like growth factors, or lipid peroxidation about 9% cases could avoided increasing However might involve confounding indirect mechanisms, such as composition other social class correlates.