A comparative study on the metabolism of Epimedium koreanum Nakai-prenylated flavonoids in rats by an intestinal enzyme (lactase phlorizin hydrolase) and intestinal flora.
作者： Jing Zhou , Yan Chen , Ying Wang , Xia Gao , Ding Qu
DOI: 10.3390/MOLECULES19010177
关键词:
摘要: The aim of this study was to compare the significance intestinal hydrolysis prenylated flavonoids in Herba Epimedii by an enzyme and flora. Flavonoids were incubated at 37 °C with rat HPLC-UV used calculate metabolic rates parent drug incubation LC/MS/MS determine chemical structures metabolites generated different flavonoid glycosides. Rates metabolism quicker than those sequence flora icariin>epimedin B>epimedin A>epimedin C>baohuoside I, whereas order C>epimedin B>baohuoside I. Meanwhile, graphs showed that icariin produced three products, epimedin A/B/C had four baohuoside I yielded one product incubations both flora, which more results due fact has lower detectability higher sensitivity. Moreover, outcomes indicated rate metabolization faster consistent results. In conclusion, pathways same components same. What's more, such as lactase phlorizin hydrolase exhibited a significant role Epimedi compared
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