The ischemic preconditioning effect of adenosine in patients with ischemic heart disease

摘要: In vivo and in vitro evidence suggests that adenosine its agonists play key roles the process of ischemic preconditioning. The effects low-dose infusion on preconditioning have not been thoroughly studied humans. We hypothesised a could reduce burden evoked by physical exercise improve regional left ventricular (LV) systolic function. nine severely symptomatic male patients with severe coronary artery disease. Myocardial ischemia was induced two separate occasions quantified Tissue Doppler Echocardiography. Prior to test, intravenous or placebo infused over ten minutes according randomized, double blind, cross-over protocol. LV walls were defined as if reduction, no increment, an increment < 15% peak velocity (PSV) observed during maximal compared baseline values prior placebo-infusion. Otherwise, non-ischemic. PSV increased from non-ischemic both (P = 0.0001) 0.0009). However, walls, only 0.001), while changes occurred NS). Low-dose reduced improved function exercise-induced myocardial ischemia, confirming is potential agent