Estrogenic effects of Sedum sarmentosum Bunge in ovariectomized rats.
作者： Won-Bee KIM , Yun-Ja PARK , Mi-Ra PARK , Tae-Yeul HA , Sang-Hyeon LEE
DOI: 10.3177/JNSV.50.100
关键词:
摘要: The aim of this study was to evaluate the effects Sedum sarmentosum Bunge (SS) on lipid serum and collagen content connective tissues in ovariecto-mized estrogen-deficient rats. Three groups were surgically ovariectomized. fourth group sham operated. From day 2 until 37 after ovariectomy, Sprague-Dawley female rats randomly assigned following groups: sham-operated (sham), ovariectomized control (OVX-control), supplemented with an ethyl ether fraction SS at 10mg/kg bw/d (OVX-EE), acetate (OVX-EA). fractions orally adminis-trated 1 mL per day. estrogenic SS, investigated using one vitro assay two vivo assays. treatment partition layers increased transcriptional activ-ity 0.7-fold 0.5-fold compared those that given 17β-estradiol treatment, respec-tively. OVX significantly heavier than all times, but supplementation extracts tended result less weight gain OVX-control. triglyceride levels decreased portion BE EA layers. Supplementation prevented a decrease level bone cartilage tissues. This indicates affects col-lagen synthesis These results are consistent conclusions based activities SS. Therefore, it may be used possibly improve quality life menopausal women.
sci-hub.se 参考文章(43)
M. Ponglikitmongkol, J. H. White, P. Chambon, Synergistic activation of transcription by the human estrogen receptor bound to tandem responsive elements. The EMBO Journal. ,vol. 9, pp. 2221- 2231 ,(1990) , 10.1002/J.1460-2075.1990.TB07392.X
N.G. Miyamoto, V. Moncollin, J.M. Egly, P. Chambon, Specific interaction between a transcription factor and the upstream element of the adenovirus-2 major late promoter. The EMBO Journal. ,vol. 4, pp. 3563- 3570 ,(1985) , 10.1002/J.1460-2075.1985.TB04118.X
Masahiko Sato, Marian K. Rippy, Henry U. Bryant, Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. The FASEB Journal. ,vol. 10, pp. 905- 912 ,(1996) , 10.1096/FASEBJ.10.8.8666168
I. Wickelgren, A New Weapon Against Alzheimer's? Science. ,vol. 276, pp. 676- 677 ,(1997) , 10.1126/SCIENCE.276.5313.676
Alice L. Murkies, Gisela Wilcox, Susan R. Davis, Clinical review 92: Phytoestrogens. The Journal of Clinical Endocrinology and Metabolism. ,vol. 83, pp. 297- 303 ,(1998) , 10.1210/JCEM.83.2.4577
Kenneth D. R. Setchell, Aedin Cassidy, Dietary Isoflavones: Biological Effects and Relevance to Human Health Journal of Nutrition. ,vol. 129, pp. 758- 758 ,(1999) , 10.1093/JN/129.3.758S
K D Setchell, Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. The American Journal of Clinical Nutrition. ,vol. 68, ,(1998) , 10.1093/AJCN/68.6.1333S
Daisaburo FUJIMOTO, Takahiko MORIGUCHI, Pyridinoline, a non-reducible crosslink of collagen. Quantitative determination, distribution, and isolation of a crosslinked peptide. Journal of Biochemistry. ,vol. 83, pp. 863- 867 ,(1978) , 10.1093/OXFORDJOURNALS.JBCHEM.A131983
H. Kikuchi-Hayakawa, N. Onodera, S. Matsubara, E. Yasuda, Y. Shimakawa, F. Ishikawa, Effects of soya milk and Bifidobacterium-fermented soya milk on plasma and liver lipids, and faecal steroids in hamsters fed on a cholesterol-free or cholesterol-enriched diet. British Journal of Nutrition. ,vol. 79, pp. 97- 105 ,(1998) , 10.1079/BJN19980013
DIKE N. KALU, CHUNG-CHING LIU, ROBERT R. HARDIN, BRUCE W. HOLLIS, The Aged Rat Model of Ovarian Hormone Deficiency Bone Loss Endocrinology. ,vol. 124, pp. 7- 16 ,(1989) , 10.1210/ENDO-124-1-7