Hyperdipsia induced by bilateral destruction of the locus coeruleus in rats.
作者： Yoshitsugu Osumi , Ryozo Oishi , Hiroshi Fujiwara , Shuji Takaori
DOI: 10.1016/0006-8993(75)90892-6
关键词:
摘要: Abstract Bilateral lesions in the locus coeruleus (LC) of rats induced a urinary disorder and hyperdipsia. Dilatation bladder, retention hematuria with bleeding originating from occurred immdiately after lesioning continued for 2–5 days. Water intake increased 4 days lesioning. This hyperdipsia persisted at least then gradually returned to control level. Food decreased first 5 days, Lesions ascending dorsal bundle (DB) LC also produced hyperdipsia, but not disorder. Destruction ventral (VB) noradrenaline (NA) neurons medulla oblongata did affect eating, drinking or urination. The LC- DB-lesioning caused significant reduction NA whole forebrain except hypothalamus, whereas VB-lesioning reduced hypothalamus. In LC-lesioned animals, no changes were observed serum osmolarity, Na + , K albumin glucose serum, excretion urine water-loading test.
elsevier.com
sci-hub.se 参考文章(27)
Shibata S, Improved technique of O-aminobiphenyl method for the determination of glucose in serum. The bulletin of the Yamaguchi Medical School. ,vol. 9, pp. 13- ,(1962)
J J Coulombe, L Favreau, A New Simple Semimicro Method for Colorimetric Determination of Urea Clinical Chemistry. ,vol. 9, pp. 102- 108 ,(1963) , 10.1093/CLINCHEM/9.1.102
Joachim F. R. König, Renate A. Klippel, The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem ,(1986)
Basil T. Doumas, W. Ard Watson, Homer G. Biggs, Albumin standards and the measurement of serum albumin with bromcresol green Clinica Chimica Acta. ,vol. 31, pp. 21- 30 ,(1997) , 10.1016/S0009-8981(96)06447-9
Philip Teitelbaum, Alan N. Epstein, The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions. Psychological Review. ,vol. 69, pp. 74- 90 ,(1962) , 10.1037/H0039285
Barbara E. Jones, Pierre Bobillier, Claude Pin, Michel Jouvet, The effect of lesions of catecholamine-containing neurons upon monoamine content of the brain and EEG and behavioral waking in the cat. Brain Research. ,vol. 58, pp. 157- 177 ,(1973) , 10.1016/0006-8993(73)90830-5
Stanley A. Lorens, Charles Y. Kondo, Effects of septal lesions on food and water intake and operant responding for food Physiology & Behavior. ,vol. 4, pp. 729- 732 ,(1969) , 10.1016/0031-9384(69)90107-3
R. R. Hutchinson, J. W. Renfrew, Modification of eating and drinking: interactions between chemical agent, deprivation state, and site of stimulation. Journal of Comparative and Physiological Psychology. ,vol. 63, pp. 408- 416 ,(1967) , 10.1037/H0024612
Jakob Korf, George K. Aghajanian, Robert H. Roth, Stimulation and destruction of the locus coeruleus: Opposite effects on 3-methoxy-4-hydroxyphenylglycol sulfate levels in the rat cerebral cortex European Journal of Pharmacology. ,vol. 21, pp. 305- 310 ,(1973) , 10.1016/0014-2999(73)90131-3
J. E. Ahlskog, B. G. Hoebel, Overeating and obesity from damage to a noradrenergic system in the brain. Science. ,vol. 182, pp. 166- 169 ,(1973) , 10.1126/SCIENCE.182.4108.166