How Can Next-Generation Sequencing (Genomics) Help Us in Treating Colorectal Cancer?

摘要: Next-generation sequencing methods have exponentially increased the amount of genomic information available to scientists and clinicians. This review will explain evolution tumor gene identify its potential accelerate therapeutic progress by using colorectal cancer illustrate benefits this type analysis. A milestone in occurred when The Cancer Genome Atlas investigators characterized genomes 276 samples, with resulting expected provide future clinical applications help guide treatment cancer. Data regarding mutational frequencies, prognostic predictive biomarker usefulness, signaling pathway alterations are emerging from various next-generation platforms. also enhancing our understanding causes consequences both chromosomal instability microsatellite pathways as well expanding knowledge origins familial Limitations include need for storage analysis massive quantities data assurance that is highest possible quality. However, technology carries it revolutionize patients through better underlying disease biology subsequent development application approaches targeting genetic abnormalities specific individual malignancies.