Ulcerative colitis neoplasia is not associated with common inflammatory bowel disease single-nucleotide polymorphisms

摘要: Background Neoplasia complicating ulcerative colitis (UC-neoplasia) is a problem that poorly addressed by present surveillance techniques. The association of greater than 300 single nucleotide polymorphisms (SNPs) with inflammatory bowel disease (IBD) suggests the possibility certain genetic might identify patients UC destined for malignant degeneration. This study tested hypothesis presently known IBD-associated SNPs may correlate UC-neoplasia. Materials and methods A total 41 UC-neoplasia (mean age 56 ± 2.1 years) were identified from our divisional IBD Biobank (low-grade dysplasia n = 13, high-grade n = 8, colorectal cancer [CRC] n = 20). These individually age, sex, duration matched without neoplasia. Primary sclerosing cholangitis family history CRC recorded. Patients genotyped 314 most commonly custom SNP microarray. Logistic regression Fischer exact test used statistical analysis. Results After Bonferroni correction, none correlated when compared controls. incidence primary was in group (10/41, 24% vs 3/41, 7%; P = .03) severity neoplasia (low grade versus high CRC) (7.9 13.4 20.7 years, respectively). Conclusion lack correlation between well-known demonstrated this development associated determinants other those predispose to inflammation or results posttranslational modifications epigenetic factors rather germline polymorphisms.