β-Catenin is a promising key factor in the SDF-1/CXCR4 axis on metastasis of pancreatic cancer☆

摘要: Summary Metastasis is recently the most fearsome of cancer. Pancreatic cancer fourth leading cause death. Morbidity and mortality from pancreatic conspicuously associated with metastasis. However, mechanism metastasis not well described. Early studies mostly focus on “soil seed” hypothesis. Recently, chemotaxis hypothesis has been paid more attention. Cancer cell high expression chemokine receptor will spread to specific sites where ligand highly secreted. It demonstrated that SDF-1/CXCR4 signaling, one important receptor–ligand complexes, was considered play a critical role in organ-specific through some possible pathways. do clarify signaling progression. β-Catenin, an factor canonical Wnt pathway, also makes great contributions invasion seems Wnt/β-catenin significant progression interactions different protein complexes. In previous study neural development, relationship between β-catenin gave clue describe correlation pathway. According this, we postulate promising key regulate With stimulation SDF-1 metastatic cells, separate translocate into nucleus, trigger target genes finally promote migration cells sites. Through observation this crosstalk, it understand clearly about make gene therapy