Role of disease-associated tolerance in infectious superspreaders

摘要: Natural populations show striking heterogeneity in their ability to transmit disease. For example, a minority of infected individuals known as superspreaders carries out the majority pathogen transmission events. In mouse model Salmonella infection, subset hosts becomes superspreaders, shedding high levels bacteria (>108 cfu per g feces) but remain asymptomatic with dampened systemic immune state. Here we that superspreader when they are treated oral antibiotics. contrast, nonsuperspreader Salmonella-infected antibiotics rapidly shed display signs morbidity. This morbidity is linked an increase inflammatory myeloid cells spleen followed by increased production acute-phase proteins and proinflammatory cytokines. The degree colonic inflammation similar antibiotic-treated hosts, indicating tolerant antibiotic-mediated perturbations intestinal tract. Importantly, neutralization cytokines antibiotic-induced suppresses expansion reduces We describe unique disease-associated tolerance facilitates continued pathogen.