2024
| 标题 | 作者 | 引用次数 |
|---|---|---|
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7 Vittoria Zoppi , Scott J Hughes , Chiara Maniaci , Andrea Testa , Teresa Gmaschitz , Corinna Wieshofer , Manfred Koegl , Kristin M Riching , Danette L Daniels , Andrea Spallarossa , Alessio Ciulli - Journal of Medicinal Chemistry, 2019 |  | 72 |
Medical Uses of Silver: History, Myths, and Scientific Evidence. Serenella Medici , Massimiliano Peana , Valeria M. Nurchi , Maria Antonietta Zoroddu - Journal of Medicinal Chemistry, 2019 |   | 49 |
Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. Yangbing Li , Jiuling Yang , Angelo Aguilar , Donna McEachern , Sally Przybranowski , Liu Liu , Chao-Yie Yang , Mi Wang , Xin Han , Shaomeng Wang - Journal of Medicinal Chemistry, 2019 | 81 | |
Antibiotic Adjuvants: Make Antibiotics Great Again! Hana Douafer , Véronique Andrieu , Otto Phanstiel , Jean Michel Brunel - Journal of Medicinal Chemistry, 2019 | 44 | |
Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms Junting Zhou , Xueyang Jiang , Siyu He , Hongli Jiang , Feng Feng , Wenyuan Liu , Wei Qu , Haopeng Sun - Journal of Medicinal Chemistry, 2019 |  | 50 |
On the Promise of Photopharmacology Using Photoswitches: A Medicinal Chemist's Perspective. Matthew J. Fuchter - Journal of Medicinal Chemistry, 2020 | 17 | |
Discovery of Cyclic Boronic Acid QPX7728, an Ultra-broad-spectrum Inhibitor of Serine and Metallo Beta-lactamases. Scott J. Hecker , K. Raja Reddy , Olga Lomovskaya , David C. Griffith , Debora Rubio-Aparicio , Kirk Nelson , Ruslan Tsivkovski , Dongxu Sun , Mojgan Sabet , Ziad Tarazi , Jonathan Parkinson , Maxim Totrov , Serge H. Boyer , Tomasz W. Glinka , Orville A. Pemberton , Yu Chen , Michael N. Dudley - Journal of Medicinal Chemistry, 2020 | 29 | |
3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma. Rui Xu , Keshi Wang , James P. Rizzi , Heli Huang , Jonas A. Grina , Stephen T. Schlachter , Bin Wang , Paul M. Wehn , Hanbiao Yang , Darryl D. Dixon , Robert M. Czerwinski , Xinlin Du , Emily L. Ged , Guangzhou Han , Huiling Tan , Tai Wong , Shanhai Xie , John A. Josey , Eli M. Wallace - Journal of Medicinal Chemistry, 2019 | 31 | |
Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug-Target Interactions. Shaoyong Lu , Jian Zhang - Journal of Medicinal Chemistry, 2018 |  | 52 |
Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. Daniela Angst , François Gessier , Philipp Janser , Anna Vulpetti , Rudolf Wälchli , Christian Beerli , Amanda Littlewood-Evans , Janet Dawson , Barbara Nuesslein-Hildesheim , Grazyna Wieczorek , Sascha Gutmann , Clemens Scheufler , Alexandra Hinniger , Alfred Zimmerlin , Enrico G. Funhoff , Robert Pulz , Bruno Cenni - Journal of Medicinal Chemistry, 2020 |   | 23 |
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria Jiajun Wang , Jing Song , Zhanyi Yang , Shiqi He , Yi Yang , Xingjun Feng , Xiujing Dou , Anshan Shan - Journal of Medicinal Chemistry, 2019 | 26 | |
Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. Meng Cheng , Xufen Yu , Kaylene Lu , Ling Xie , Li Wang , Fanye Meng , Xiaoran Han , Xian Chen , Jing Liu , Yue Xiong , Jian Jin - Journal of Medicinal Chemistry, 2020 |     | 22 |
Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance Barbara Parrino , Daniela Carbone , Domenico Schillaci , Elisa Giovannetti , Girolamo Cirrincione , Patrizia Diana , Stella Cascioferro - Journal of Medicinal Chemistry, 2020 |  | 20 |
Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors. Sara Cherry , Yan Xiang , David Schultz , Michael Thomas Marty , Chunlong Ma , Xiangzhi Meng , Yu Chen , Yanmei Hu , Jun Wang , Xiujun Zhang , Fushun Zhang , Naoya Kitamura , Julia Alma Townsend , Tommy Szeto , Michael Dominic Sacco , Adis Kukuljac , Mandy Ba - Journal of Medicinal Chemistry, 2021 |       | 0 |
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mice Models Deyin Guo , Jincun Zhao , Yu Zhang , Yunfeng Li , Yanxi Ji , Guanguan Li , Yingjun Li , Jing Sun , Xumu Zhang , Yinzhu Luo , Ge Li , Feng Cong , Liu Cao , Guijiang Chen , Ping Wang , Fan Xing - bioRxiv, 2020 | 2 | |
Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding Kevin McCloskey , Eric A. Sigel , Steven Kearnes , Ling Xue , Xia Tian , Dennis Moccia , Diana Gikunju , Sana Bazzaz , Betty Chan , Matthew A. Clark , John W. Cuozzo , Marie-Aude Guié , John P. Guilinger , Christelle Huguet , Christopher D. Hupp , Anthony D. Keefe , Christopher J. Mulhern , Ying Zhang , Patrick Riley - Journal of Medicinal Chemistry, 2020 |     | 13 |
Investigation of the adrenergic and opioid binding affinities, metabolic stability, plasma protein binding properties, and functional effects of selected indole-based kratom alkaloids Samuel Obeng , Shyam H Kamble , Morgan E Reeves , Luis F Restrepo , Avi Patel , Mira Behnke , Nelson J-Y Chear , Surash Ramanathan , Abhisheak Sharma , Francisco León , Takato Hiranita , Bonnie A Avery , Lance R McMahon , Christopher R McCurdy - Journal of medicinal chemistry, 2019 |       | 113 |
Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases. Richard D. Caldwell , Hui Qiu , Ben C. Askew , Andrew T. Bender , Nadia Brugger , Montserrat Camps , Mohanraj Dhanabal , Vikram Dutt , Thomas Eichhorn , Anna S. Gardberg , Andreas Goutopoulos , Roland Grenningloh , Jared Head , Brian Healey , Brian L. Hodous , Bayard R. Huck , Theresa L. Johnson , Christopher Jones , Reinaldo C. Jones , Igor Mochalkin , Federica Morandi , Ngan Nguyen , Michael Meyring , Justin R. Potnick , Dusica Cvetinovic Santos , Ralf Schmidt , Brian Sherer , Adam Shutes , Klaus Urbahns , Ariele Viacava Follis , Ansgar A. Wegener , Simone C. Zimmerli , Lesley Liu-Bujalski - Journal of Medicinal Chemistry, 2019 |   | 21 |
1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. Zhi Xu , Shi-Jia Zhao , Yi Liu - European Journal of Medicinal Chemistry, 2019 | 83 | |
An insight into the medicinal perspective of synthetic analogs of indole: A review. Punniyakoti Veeraveedu Thanikachalam , Rahul Kumar Maurya , Vishali Garg , Vikramdeep Monga - European Journal of Medicinal Chemistry, 2019 |   | 48 |