Exercise improves cognition and hippocampal plasticity in APOE ε4 mice

摘要: Abstract Background Human studies on exercise, cognition, and apolipoprotein E ( APOE ) genotype show that e4 carriers may benefit from regular physical activity. Methods We examined voluntary wheel-running, memory, hippocampal plasticity in e3 transgenic mice at 10–12 months of age. Results Sedentary exhibited deficits cognition the radial-arm water maze (RAWM), a task dependent hippocampus. Six weeks wheel-running resulted improvements RAWM to level mice. Hippocampal brain-derived neurotrophic factor (BDNF) levels were similar mice, after exercise BDNF was similarly increased both In sedentary tyrosine kinase B (Trk B) receptors reduced by 50%. Exercise restored Trk dramatically synaptophysin, marker synaptic function. Conclusions Our results support hypothesis can improve cognitive function, particularly carriers.