Retardation of experimental oral cancer by topical vitamin E

摘要: Abstract Forty‐eight young male and female golden hamsters (Mesocricetus auratus) were divided into four groups of 12 animals each. The left buccal pouches Group 1 2 painted 3 times weekly with a 0.5% solution 7,12‐dimethyl‐benz(a)anthracene (DMBA) in heavy mineral oil for 7 weeks. At the end this period, vitamin E (DL‐α‐tocopherol, pure form) an additional 4 only, untreated controls. demonstrated significant delay tumor formation comparison animals. Gross observation revealed fewer smaller tumors animals; microscopic examination better cellular differentiation less invasion. No observed These observations similar to those made previous studies oral carcinogenesis using sys...