Heterogeneity of kinase inhibitor resistance mechanisms in GIST

作者: B Liegl , I Kepten , C Le , M Zhu , GD Demetri

DOI: 10.1002/PATH.2382

关键词: PathologyTyrosine kinaseImatinibBiologyCD117Cancer researchGiSTPDGFRASunitinibImatinib mesylateGene duplication

摘要: … Most GIST patients develop clinical resistance to KIT/PDGFRA tyrosine kinase inhibitors (TKI). However, it is unclear whether clinical resistance results from single or multiple molecular …

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