Assessment of Indian Rosewood (Dalbergia sissoo) Standardized Leaf Extract on Isoproterenol-Induced Myocardial Injury in Rats
作者： Jaya Kiran Kasa , Thakur Uttam Singh , Subhashree Parida , M Pule Addison , Sajad Ahmad Darzi
DOI: 10.1007/S12012-014-9292-9
关键词: Endocrinology 、 Histopathology 、 Cholesterol 、 Glutathione 、 Heart rate 、 Oxidative stress 、 Mean arterial pressure 、 Surgery 、 Superoxide dismutase 、 Medicine 、 Internal medicine 、 Triglyceride
摘要: The present study was undertaken to evaluate the effect of alcoholic extract Dalbergia sissoo leaf (DSE) on isoproterenol (ISP)-induced myocardial injury in rats. Evaluation three doses (30, 100 and 300 mg/kg body weight) DSE done ISP-treated ISP used at 85 weight by subcutaneous route for two subsequent days induce Assessment estimation different cardiac markers like LDH, CK-MB. Serum cholesterol, LDL, HDL, triglycerides serum, infarcted area, oxidative stress histopathology heart tissue were also assessed Mean arterial pressure rate recorded all groups. Rats pretreated with showed significant (p < 0.05-0.001) improvement weight/body ratio, areas, mean ISP-induced injury. serum CK-MB, LDL triglyceride levels dose levels. However, pretreatment had no HDL level. Pretreatment 0.001) reduction MDA level comparison injured Further, antioxidant potential improved terms activities reduced glutathione, superoxide dismutase catalase pretreatment. Histopathology tissue. suggests that beneficial
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