ACTH Regulates Steroidogenic Gene Expression and Cortisol Biosynthesis in the Human Adrenal Cortex via Sphingolipid Metabolism
作者： Tuba Ozbay , Alfred H. Merrill , Marion B. Sewer
关键词: Cell signaling 、 Biochemistry 、 Sphingosine 、 Signal transduction 、 Ceramide 、 ACTH receptor 、 Adrenal cortex 、 Sphingomyelin 、 Biology 、 Sphingolipid
摘要: Sphingolipids are a diverse family of phospholipids and glycolipids that mediate cell‐cell interactions, participate in signal transduction pathways modulate the activity various cellular proteins receptors. The objective present studies was to characterize role sphingolipid biosynthetic pathway adrenocorticotropin (ACTH)‐dependent steroidogenic gene expression cortisol production. H295R human adrenocortical cells were treated with ACTH or dibutyryl cAMP (Bt2cAMP) for time periods content sphingolipids quantified by mass spectrometry. Treatment Bt2cAMP activated metabolism within five minutes. Decreases found levels several sphingolipids, including sphingomyelin (SM) glucosylceramide. ACTH/cAMP rapidly decreased signaling molecules ceramide, sphingosine, sphingosine‐1‐phosphate (S1P). effect these bioactive on ...
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