Effect of Peroxidative Conditions on Human Plasma Low-Density Lipoproteins

摘要: Human low-density lipoprotein (LDL) is a spherical particle with diameter of 220 A and molecular weight about 2.5 million. LDL consists an interior core esterified cholesterol (about 1500 molecules) outer shell 800 molecules phospholipids 500 free molecules. Embedded in the apolipoprotein B-100, large protein 500000, which recognized by receptor (Goldstein Brown 1978) present on surface most cells largely responsible for controlled catabolism LDL. It well established that main carrier blood-stream increased levels correlate risk atherosclerosis. Early atherosclerotic lesions are characterized deposits lipid laden foam derived from monocyte macrophages. Macrophages possess two types LDL, one enables uptake process downregulated internalized cholesterol. Uptake this cannot, therefore, lead to lipid-laden cells. In addition classical receptor, macrophages posses scavenger recognizing modified apo B. Goldstein (1983) were first show treated acetic acid anhydride (acetyl-LDL) taken up through not cholsterol incubated vitro acetyl-LDL developed cell like appearance. Since acetylation does occur vivo, question remained, if, what mechanism, altered way makes it recognizable receptor. Recent studies several laboratories (Henrikson et al. 1981; Morel 1984; Heinecke 1986; 1987) suggest can become oxidized attack oxygen radicals. converts into Moreover, shows many other features characteristic early events atherogenesis (for review see Jurgens 1987). Thus, was found chemotactic circulating monocytes but inhibits further migration resident Furthermore, cytotoxic towards its accumulation would therefore death arterial wall