Cones of skin occur where hypertrophic scar occurs

摘要: Hypertrophic scarring is devastating for the patient, however pathophysiology and treatment remain unknown after decades of research. The process follows deep dermal injury, occurs only on certain body parts, does not occur in early fetus or animals, a localized event. This suggests that an anatomic structure human, dermis may be involved. matrix perforated by cones containing many structures including skin appendages fat domes. We hypothesized studying might reveal related to scarring. examined tangential wounds from various parts human cadavers along with histology fetus, partial thickness burns, hypertrophic scars, two other species-rats rabbits. found fact structure. They exist where scar occurs-cheek, neck, chest, abdomen, back, buttock, arm, forearm, dorsal hand, thigh, leg, foot, helix ear lobe. do occur-scalp, forehead, concha, eyelid, palm, rat, rabbit. It also became apparent have been omitted most considerations histology. suggest need studied relation restored diagrams.