Cerebellar amyloid-β plaques: disturbed cortical circuitry in AβPP/PS1 transgenic mice as a model of familial Alzheimer's disease.

作者: Selene Lomoio , Irene López-González , Ester Aso , Margarita Carmona , Benjamín Torrejón-Escribano

DOI: 10.3233/JAD-2012-112198

关键词: Genetically modified mouseDendritic spineExtracellularCerebellumSenile plaquesTransgeneIntracellularPurkinje cellPathologyBiology

摘要: … parallel fibers as the main component of dystrophic neurites of Aß plaques, loss of synaptic … tion [29–34], and that maintenance of Aß oligomers does not impair disease progression in …

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