Cancer surveillance strategies in ulcerative colitis: the need for modernization.

摘要: The risk of colorectal cancer is increased in patients with longstanding ulcerative colitis. Traditional surveillance has centered around regular standard white-light colonoscopy, multiple biopsies aimed at detecting dysplasia or the identification early cancer. This resulted only a modest reduction incidence and mortality. A better understanding disease factors may allow endoscopic resources to be more focused on higher risk. In addition, advanced techniques have potential improve detection, minimize need for routine biopsies, removal dysplastic lesions, avoiding surgery. Techniques such as magnification chromoendoscopy, narrow band imaging, autofluorescence, confocal endomicroscopy all role play improving benefits surveillance. Revised strategies are proposed, incorporating aspects stratification, well-established practice noncolitis-related screening, some these new technologies. (Inflamm Bowel Dis 2010;)