A dual chicken IgY against rotavirus and norovirus.
作者： Ying-Chun Dai , Xu-Fu Zhang , Ming Tan , Pengwei Huang , Wen Lei
DOI: 10.1016/J.ANTIVIRAL.2012.12.011
关键词: Immunization 、 Antibody 、 Virology 、 Neutralization 、 Microbiology 、 Norovirus 、 Rotavirus 、 Antigen 、 Diarrhea 、 Titer 、 Biology
摘要: Rotavirus (RV) and norovirus (NoV) are the two most important causes of viral gastroenteritis. While vaccine remains an effective prophylactic strategy, development other approaches, such as passive immunization to control treat clinical infection illness these pathogens, is necessary. Previously we demonstrated that high titers NoV-specific IgY were readily developed by chickens with NoV P particles. In this study, a dual against both RV through divalent comprising neutralizing antigens NoV. This vaccine, named P-VP8(∗) particle, made particle carrier spike protein VP8(∗) surface insertion. Approximately 45mg obtained from each yolk anti-P anti-VP8(∗) antibodies detected ELISA, Western blot, HBGA blocking (NoV RV) neutralization assays. Reductions replication observed viruses treated before after inoculation into cells, suggesting application therapeutic treatment. Collectively, our data suggested based could serve practical approach RV.
sci-hub.se 参考文章(37)
Roger I. Glass, Joseph Bresee, Baoming Jiang, Jon Gentsch, Tamie Ando, Rebecca Fankhauser, Jacqueline Noel, Umesh Parashar, Blair Rosen, Stephan S. Monroe, Gastroenteritis viruses: an overview. Novartis Foundation symposium. ,vol. 238, pp. 5- 25 ,(2008) , 10.1002/0470846534.CH2
Yves Beckers, André Théwis, Daniel Portetelle, Raja Chalghoumi, Hen egg yolk antibodies (IgY), production and use for passive immunization against bacterial enteric infections in chicken: a review Biotechnologie, Agronomie, Société et Environnement. ,vol. 13, pp. 295- 308 ,(2009)
C. Vega, M. Bok, P. Chacana, L. Saif, F. Fernandez, V. Parreño, Egg yolk IgY: protection against rotavirus induced diarrhea and modulatory effect on the systemic and mucosal antibody responses in newborn calves. Veterinary Immunology and Immunopathology. ,vol. 142, pp. 156- 169 ,(2011) , 10.1016/J.VETIMM.2011.05.003
Manish Patel, Andi L. Shane, Umesh D. Parashar, Baoming Jiang, Jon R. Gentsch, Roger I. Glass, Oral Rotavirus Vaccines: How Well Will They Work Where They Are Needed Most? The Journal of Infectious Diseases. ,vol. 200, ,(2009) , 10.1086/605035
Marie-Soleil Gauthier, Elena L O’Brien, Sherman Bigornia, Melanie Mott, Jose M Cacicedo, X. Julia Xu, Noyan Gokce, Caroline Apovian, Neil Ruderman, Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans Biochemical and Biophysical Research Communications. ,vol. 404, pp. 382- 387 ,(2011) , 10.1016/J.BBRC.2010.11.127
Vanessa Salete de Paula, Alexandre dos Santos da Silva, Gentil Arthur Lins Bentes Mendonça de Vasconcelos, Ezio Tavares Iff, Maria Eduarda Monteiro Silva, Livia Abud Kappel, Paula Borba Cruz, Marcelo Alves Pinto, Applied biotechnology for production of immunoglobulin Y specific to hepatitis A virus. Journal of Virological Methods. ,vol. 171, pp. 102- 106 ,(2011) , 10.1016/J.JVIROMET.2010.10.008
K. Nurminen, V. Blazevic, L. Huhti, S. Räsänen, T. Koho, V.P. Hytönen, T. Vesikari, Prevalence of norovirus GII-4 antibodies in Finnish children. Journal of Medical Virology. ,vol. 83, pp. 525- 531 ,(2011) , 10.1002/JMV.21990
Amanda Reeck, Owen Kavanagh, Mary K. Estes, Antone R. Opekun, Mark A. Gilger, David Y. Graham, Robert L. Atmar, Serological Correlate of Protection against Norovirus-Induced Gastroenteritis The Journal of Infectious Diseases. ,vol. 202, pp. 1212- 1218 ,(2010) , 10.1086/656364
Jennifer KOVACS-NOLAN, Dongwan YOO, Yoshinori MINE, Fine mapping of sequential neutralization epitopes on the subunit protein VP8 of human rotavirus Biochemical Journal. ,vol. 376, pp. 269- 275 ,(2003) , 10.1042/BJ20021969
Huan H. Nguyen, Terrence M. Tumpey, Hae-Jung Park, Young-Ho Byun, Linh D. Tran, Van D. Nguyen, Paul E. Kilgore, Cecil Czerkinsky, Jacqueline M. Katz, Baik Lin Seong, Jae Min Song, Young Bong Kim, Hoa T. Do, Tung Nguyen, Cam V. Nguyen, Prophylactic and Therapeutic Efficacy of Avian Antibodies Against Influenza Virus H5N1 and H1N1 in Mice PLoS ONE. ,vol. 5, pp. e10152- ,(2010) , 10.1371/JOURNAL.PONE.0010152