T cell responses in dengue viral infections

摘要: Dengue viral infections are the commonest mosquito borne infection in world, affecting more than 100 countries and 390 million individuals annually. Currently, there no effective antiviral drugs or an vaccine to prevent infection. A main hurdle developing a safe has been our poor understanding of complex nature protective immune response acute dengue presence four virus (DV) serotypes that highly homologous. The role DV specific T cells pathogenesis severe clinical disease not clear. It speculated cross reactive for previous infecting heterologous serotype, which produce pro-inflammatory cytokines, contribute pathogenesis. These believed be suboptimal clearing with current DV-serotype. However, other studies have shown cross-reactive DV-specific absent present very low frequency during infection, appearing only convalescent period majority patients. Furthermore, significant apoptosis occurs disease. Overall therefore, it is unclear what play contributing Existing data complicated by cross-reactivity assays. findings can now re-evaluated light novel technologies identify serotype-specific cell responses.