Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep–wake cycle and narcoleptic episodes in Ox−/− mice
作者： RX Guo , C Anaclet , JC Roberts , R Parmentier , M Zhang
DOI: 10.1111/J.1476-5381.2009.00205.X
关键词: Wakefulness 、 Narcolepsy 、 Dosing 、 Histamine H3 receptor 、 Psychology 、 Sleep disorder 、 Endocrinology 、 Orexin 、 Modafinil 、 H3 receptor antagonist 、 Internal medicine
摘要: Background and purpose: Histamine H3 receptor antagonists are currently being evaluated in clinical trials for a number of central nervous system disorders including narcolepsy. These agents can increase wakefulness (W) cats rodents following acute administration, but their effects after repeat dosing have not been reported previously.
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