The β-Sheet Structure-Stabilizing Potential of Twenty Kinds of Amino Acid Residues in Protected Peptides
作者： Mitsuaki Narita , Yoshihisa Kojima
DOI: 10.1246/BCSJ.62.3572
关键词: Dichloromethane 、 Amino acid residue 、 Beta sheet 、 HEXA 、 Inclusion compound 、 Chemistry 、 Side chain 、 Stereochemistry 、 Peptide synthesis 、 General chemistry
摘要: A host–guest approach was devised to investigate the β-sheet structure-stabilizing potential of 20 common amino acid residues in protected peptides where functional groups side chains were by suitable commonly used peptide synthesis. The evaluated using solvent-titration curves for disruption structure cross-linked polystyrene resin-bound hexa- and octapeptides CH2Cl2 HFIP. hexapeptides, Boc–Val–Ile–X2–Val–Ile-NHCH2–resins, which X stands guest residues, disrupted adding increasing amounts HFIP; behaviors strongly dependent on nature residues. scale kinds could be derived at 0.25 M HFIP concentration as follows: Ile, Val>>Asn>His(Tos) or His, Gln, Cys(Bzl), Tyr(Bzl)>Phe, Gly, Lys(Z), Arg(Tos), Leu>Thr(Bzl), Ala, Met(O...
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