Effects of vinyl chloride in man a cytogenetic follow-up study

摘要: Summary Cytogenetic studies were performed on 39 workers from a PVC plant in 1974. 16 healthy men without any connection with the chosen as controls. The cytogenetic study was repeated for 37 of 2–2.5 years later. During this time interval had only minimal exposure to VCM. This 32 matched controls office employees factory. Breaks, gaps and stable rearrangements scored 100 metaphases per person 48-h lymphocyte cultures. mean chromosome-breakage frequency (3.41%) significantly higher than (1.79%) first investigation. In no difference found between their Neither there these breakage frequencies previous control group. These results might indicate relationship reduction VCM normalized chromosomebreakage frequency. Sister-chromatid exchanges studied study. A 7.6 SCEs cell both Bone-marrow samples 4 bone marrows (4.2%) that reported normal (0.2, 0.4, 1.7%), corresponding