Human herpesvirus 7.

摘要: Human herpesvirus 7, reported in 1990 is a lymphotropic member of the betaherpesvirus subfamily herpesviruses. The virus highly seroprevalent, primary infection usually occurs during childhood, and it has been associated with cases exanthem subitum, pityriasis rosea, neurological manifestations transplant complications. latter two may warrant antiviral intervention, vitro studies have shown that HHV-7 susceptible to several nucleoside phosphonate compounds. In vitro, approximately 5 day growth cycle cultured lymphocytes; vivo, latency established peripheral blood T-cells persistent salivary gland tissue from which infectious constitutively shed saliva. genome 145 kb encodes at least 84 different proteins. Studies characterising gene products required interactions between viral cellular genes necessary for replication, persistence are their infancy. variety effects on host cells including upregulation interleukin 15 down-modulation cell surface molecule CD4; serves as membrane receptor HHV-7. Since HIV also infects via CD4 molecule, these viruses within course AIDS important areas investigation.