Human herpesvirus 7 in dermatology: what role does it play?

摘要: Human herpesvirus 7 (HHV-7) was discovered in 1989 as a new member of the s-herpesvirus subfamily. Primary infection occurs early life and manifests exanthema subitum, or other febrile illnesses mimicking measles rubella. Thus, HHV-7 has to be considered causative agent variety macular-papular rashes children. In addition, found some cases inflammatory skin disorders, such psoriasis. There are controversial data on detection pityriasis rosea, but so far there is not enough evidence for pathogenetic association with this exanthematic disease. Although can Hodgkin’s disease, no supporting direct role lymphoma type nor nodal primary cutaneous lymphomas. various epidemiologic forms Kaposi’s sarcoma, monocytic cells demonstrated, which may indirectly influence tumor biology. context immunosuppression, recently been identified an emerging pathogen transplant recipients exacerbate graft rejection renal recipients. The ability induce cytokine production infected could make important co-factor neoplastic disorders. Moreover, restricted cellular tropism render virus interesting vector gene therapy. Thirteen years after discovery HHV-7, considerable progress characterizing its genetic structure, virus-induced effects host development diagnostic tools. Nevertheless, diseases clinical manifestations reactivation have still defined.