Effects of Toll-like receptor 4 on Porphyromonas gingivalis-induced bone loss in mice.
作者： M. Costalonga , L. Batas , B. J. Reich
DOI: 10.1111/J.1600-0765.2008.01152.X
关键词: Myeloid 、 Lipopolysaccharide 、 Porphyromonas gingivalis 、 Osteopenia 、 Biology 、 Dental alveolus 、 Ratón 、 Antigen-presenting cell 、 Molecular biology 、 Pathology 、 Toll-like receptor
摘要: Background and Objective: Toll-like receptor 4 (TLR-4)/myeloid differentiation protein-2 complex ligation by lipopolysaccharide induces production of pro-inflammatory cytokines co-stimulatory molecules on antigen presenting cells. The aim this study was to determine the role TLR-4 in bone loss-resistant C57BL mice loss-susceptible BALB/c after infection with Porphyromonas gingivalis. Material Methods: C57BL/10 mice, either normal or deficient, were infected sham-infected orally four times, at 4 day intervals, 109 colony forming units P. gingivalis. At 47 days, defleshed jaws stained photographed a standardized position. We measured surface area root trunk assess alveolar loss. Results: Porphyromonas gingivalis-infected wild-type lost 13.8% more than P. gingivalis-infected mice. In contrast, TLR-4-deficient 12.7% C57BL/6 TLR-2 knockout had similar levels control mice. Conclusion: is protective for but detrimental since its absence allowed not lose bone. receptor 2 does contribute protection genetically
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