Exploring new biomarkers in the tumour microenvironment of canine inflammatory mammary tumours.
作者： T. P. Raposo , I. Pires , J. Prada , F. L. Queiroga , D. J. Argyle
DOI: 10.1111/VCO.12209
关键词: Metastasis 、 Vascular endothelial growth factor A 、 Cancer research 、 Inflammatory breast cancer 、 Biology 、 Tumor microenvironment 、 Cancer 、 Canine Mammary Carcinoma 、 Carcinogenesis 、 Vascular endothelial growth factor 、 Pathology
摘要: Human inflammatory breast cancer (IBC) and canine mammary (CIMC) are the most aggressive forms of cancer. Current research aims to identify new therapeutic targets. Here, we investigated gene expression levels biomarkers associated with microenvironment. A total 32 formalin-fixed paraffin-embedded samples carcinoma (CIMC = 26; non-CIMC = 6) were used their cDNA subjected quantitative polymerase chain reaction (qPCR) establish for mediators commonly implicated in linking carcinogenesis inflammation. Gene differences between CIMC non-CIMC types obtained cyclooxygenase 2 (COX-2) (P = 0.004), synuclein gamma (SNCG) (P = 0.006), tribbles 1 (P = 0.025), vascular endothelial growth factor (VEGF) (P = 0.017) CSF1R (P = 0.045). Among these correlations found, particularly SNCG (r = 0.512, P = 0.001). The efficient metastasis is intimately linked components tumour This study suggests that upregulation correlation deserves be further explored.
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