Selective Impairment of Pancreatic A Cell Suppression by Glucose during Acute Alloxan-Induced Insulinopenia: In Vitro Study on Isolated Perfused Rat Pancreas
作者： P. FILIPPONI , F. GREGORIO , S. CRISTALLINI , C. FERRANDINA , I. NICOLETTI
关键词: Alloxan 、 Endocrinology 、 Glucagon 、 Insulin 、 Internal medicine 、 Biology 、 Infusion Procedure 、 Pancreas 、 Peptide hormone 、 Glucagon secretion 、 Arginine
摘要: This study was performed in order to investigate the role of insulin modulation pancreatic A cell response glucose. The isolated perfused rat pancreas model used: intraislet insulinopenia induced vitro by 0.56 mm alloxan infusion over 15 min. Alloxan caused a transitory release but did not affect glucagon secretion. Exposure completely abolished 20 arginine, 1.6 glucose, and 11.1 Glucagon arginine glucose unchanged pretreatment compared control pancreata treated with alloxan. However, suppression experiments. Twenty milliunits per ml infused during restored glycemic release, it produced only slight inhibitory effect on function presence 3.9 Our indicates that is physiological suppressor ...
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