The therapeutic response of bronchial carcinoma xenografts: a direct patient-xenograft comparison.
作者： M J Peckham , J F Smyth , G G Steel , A J Shorthouse
DOI:
关键词: Chemotherapy 、 Internal medicine 、 Carcinoma 、 Medicine 、 Transplantation 、 Large cell 、 Oncology 、 Bronchial neoplasm 、 Neoplasm 、 Heterologous 、 Histology
摘要: The chemotherapeutic response of a series patients with bronchial carcinoma has been compared the their xenografts established in immune-suppressed CBA/lac mice. Xenograft was assessed by situ endpoint growth delay subcutaneous tumours. Histology and chromosome analysis indicated that human characteristics were retained xenografts. 49 xenograft lines attempted: 15/18 oat cell, 11/17 squamous, 6/8 large cell anaplastic 6/6 adenocarcinomas successfully established. 14 Lines (28%) available (August 1979) for direct comparison donor patient to same agents. A positive correlation found provides support validity
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